Maternal and Infant Genetic Contributions to Preterm Birth: the Inflammatory Response

Project Timeline: 3/1/2006-2/28/2009

This study aimed to characterize the nature and strength oft he relationship between risk of spontaneous very preterm birth and: maternal and/or infant polymorphisms in genes other researchers have previously identified as well as genes not studied in previous studies; gene-gene interactions between pathways, mother and infant; and gene-environment interactions.

The study was comprised of three ethnicity-specific nested case-control samples from a population-based linked cohort of prenatally screened women delivering live births in southern California over a 7-year period. A total of 1,242 very preterm births of all causes and types prior to hospital chart abstraction were identified from the linked 7-year cohort, of which approximately half were anticipated to be spontaneous very preterm births after exclusion of medically indicated very preterm births.